FDA approves new targeted breast cancer drug

WASHINGTON (AP) — The Food and Drug Administration has approved a first-of-a-kind breast cancer medication that targets tumor cells while sparing healthy ones.

The drug Kadcyla from Roche combines the established drug Herceptin with a powerful chemotherapy drug and a third chemical linking the medicines together. The chemical keeps the cocktail intact until it binds to a cancer cell, delivering a potent dose of anti-tumor poison.

Cancer researchers say the drug is an important step forward because it delivers more medication while reducing the unpleasant side effects of chemotherapy.

"This antibody goes seeking out the tumor cells, gets internalized and then explodes them from within. So it's very kind and gentle on the patients — there's no hair loss, no nausea, no vomiting," said Dr. Melody Cobleigh of Rush University Medical Center. "It's a revolutionary way of treating cancer."

Cobleigh helped conduct the key studies of the drug at the Chicago facility.

The FDA approved the new treatment for about 20 percent of breast cancer patients with a form of the disease that is typically more aggressive and less responsive to hormone therapy. These patients have tumors that overproduce a protein known as HER-2. Breast cancer is the second most deadly form of cancer in U.S. women, and is expected to kill more than 39,000 Americans this year, according to the National Cancer Institute.

The approval will help Roche's Genentech unit build on the blockbuster success of Herceptin, which has long dominated the breast cancer marketplace. The drug had sales of roughly $6 billion last year.

Genentech said Friday that Kadcyla will cost $9,800 per month, compared to $4,500 per month for regular Herceptin. The company estimates a full course of Kadcyla, about nine months of medicine, will cost $94,000.

FDA scientists said they approved the drug based on company studies showing Kadcyla delayed the progression of breast cancer by several months. Researchers reported last year that patients treated with the drug lived 9.6 months before death or the spread of their disease, compared with a little more than six months for patients treated with two other standard drugs, Tykerb and Xeloda.

Overall, patients taking Kadcyla lived about 2.6 years, compared with 2 years for patients taking the other drugs.

FDA specifically approved the drug for patients with advanced breast cancer who have already been treated with Herceptin and taxane, a widely used chemotherapy drug. Doctors are not required to follow FDA prescribing guidelines, and cancer researchers say the drug could have great potential in patients with earlier forms of breast cancer

Kadcyla will carry a boxed warning, the most severe type, alerting doctors and patients that the drug can cause liver toxicity, heart problems and potentially death. The drug can also cause severe birth defects and should not be used by pregnant women.

Kadcyla was developed by South San Francisco-based Genentech using drug-binding technology licensed from Waltham, Mass.-based ImmunoGen. The company developed the chemical that keeps the drug cocktail together and is scheduled to receive a $10.5 million payment from Genentech on the FDA decision. The company will also receive additional royalties on the drug's sales.

Shares of ImmunoGen Inc. rose 2 cents to $14.32 in afternoon trading. The stock has ttraded in a 52-wek range of $10.85 to $18.10.

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Oscar Pistorius Granted Bail in Murder Case

Oscar Pistorius was granted bail today in a South African court, meaning he can be released from jail for the six to eight months before his trial for the allegedly premeditated killing of his girlfriend Reeva Steenkamp.

Magistrate Desmond Nair, in reading his lengthy decision, said, "The issue before me is whether this accused, being who is and the assets he has [here], would seek to duck and dive all over the world."
His conclusion:
"I cannot find that he is a flight risk."

Nair said, "The accused has made a case to be released on bail."

PHOTOS: Paralympics Champion Charged in Killing

The judge also said he had to weigh whether Pistorius would be a danger to others. He noted that Pistorius has been accused of using foul language against people in arguments and once threatened to break someone's legs, but he said that was different from someone with an arrest record of violence.

"I appreciate that a person is dead, but I don't think that is enough," he said.

Nair also said he could not be influenced by the public's "shock and outrage" if Pistorius is released.

A member of Pistorius' defense team told ABC News, "he is going to be released today."

Despite the ruling, prosecutors displayed confidence, with one of them emerging from the courthouse today to say, "We still believe we have the evidence to convict Oscar Pistorius."

The court set bail at about $113,000 (1 million rand) and June 4 as the date for Pistorius' next court appearance.

The other bail conditions are: Pistorius cannot leave the country; he must hand over his passports; he cannot return to his home as long as it's an active crime scene; he needs permission to leave the Pretoria area; he must visit a police station on a daily basis and be available to a probation officer at all times via cellphone; he is not allowed any communication with prosecution witnesses; he cannot drink alcohol; and he must relinquish his firearms.

"Do you understand?" the magistrate asked him.

"Yes, sir," Pistorius replied.

Alexander Joe/AFP/Getty Images

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Speaking for the family, Arnold Pistorius, the Olympian's uncle, said, "Although we are obviously relieved that Oscar has been granted bail, this is still a very sad time for the family of Reeva and for us.

"We are grateful that the Magistrate recognized the validity and strength of our application. As the family, we are convinced that Oscar's version of what happened on that terrible night will prove to be true."

The judge's ruling came on the fourth and final day of the bail hearing for Pistorius, the Olympian accused of murdering his girlfriend on Valentine's Day.

Pistorius, who gained global acclaim for racing at the 2012 London Olympics, shot his model-girlfriend through a closed bathroom. He says he killed Reeva Steenkamp accidentally, but prosecutors alleged that he took a moment to put on his prosthetic legs, indicating that he thought out and planned to kill Steenkamp when he shot her three times through the bathroom door.

Pistorius sobbed today in court. Barry Roux, his defense attorney, said the prosecution misinterpreted the assigning of intent, meaning that the runner's intent to shoot at a supposed intruder in his home cannot be transferred to someone else who was shot -- in this case, Steenkamp.

"He did not want to kill Reeva," Roux told the court.

FULL COVERAGE: Oscar Pistorius Case

When Magistrate Nair, who overheard the bail hearing, asked Roux what the charges should be if Pistorius intended to kill an intruder, the defense attorney responded that he should be charged with culpable homicide.

Culpable homicide is defined in South Africa as "the unlawful negligent killing of a human being."

Roux also made light of the prosecution's argument that Pistorius is a flight risk, saying that every time the double-amputee goes through airport security, it causes a commotion. He said that Pistorius' legs need constant maintenance and he needs medical attention for his stumps.

The prosecution argued today that the onus was on Pistorius to provide his version of events, and his version was improbable.

Prosecutor Gerrie Nel also spoke of Pistorius' fame and his disability, even relating him to Wikipedia founder Julian Assange, who is now confined to Ecuador's London Embassy, where he has been granted political asylum.
"[Assange's] facial features are as well known as Mr. Pistorius' prostheses," Nel said.

Nel argued that Pistorius' prostheses do not set him apart, stating that it's no different to any other feature, and the court cannot be seen to treat people with disabilities accused of a crime, or famous people accused of crime, any differently.

Pistorius has said that in the early hours of Feb. 14 he was closing his balcony doors when he heard a noise from the bathroom. Fearing an intruder, and without his prosthetic legs on, he grabbed a gun from under his bed and fired through the closed bathroom door, he told the court.

But prosecutors say that's implausible, that the gun's holster was found under the side of the bed where Steenkamp slept, and that Pistorius would have seen she wasn't there. Prosecutors also say the angle at which the shots were fired shows Pistorius was already wearing his prosthetics when he fired.

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French, Malian forces fight Islamist rebels in Gao

GAO, Mali (Reuters) - French and Malian troops fought Islamists on the streets of Gao and a car bomb exploded in Kidal on Thursday, as fighting showed little sign of abating weeks before France plans to start withdrawing some forces.

Reuters reporters in Gao in the country's desert north said French and Malian forces fired at the mayor's office with heavy machineguns after Islamists were reported to have infiltrated the Niger River town during a night of explosions and gunfire.

French Defense Minister Jean-Yves Le Drian told a news conference in Brussels that Gao was back under control after clashes earlier in the day.

"Malian troops supported by French soldiers killed five jihadists and the situation is back to normal," he said.

In Kidal, a remote far north town where the French are hunting Islamists, residents said a car bomb killed two. A French defense ministry source reported no French casualties.

French troops dispatched to root out rebels with links to al Qaeda swiftly retook northern towns last month. But they now risk being bogged down in a guerrilla conflict as they try to help Mali's weak army counter bombings and raids.

"There was an infiltration by Islamists overnight and there is shooting all over the place," Sadou Harouna Diallo, Gao's mayor, told Reuters by telephone earlier in the day, saying he was not in his office at the time.

Gao is a French hub for operations in the Kidal region, about 300 km (190 miles) northeast, where many Islamist leaders are thought to have retreated and foreign hostages may be held.

"They are black and two were disguised as women," a Malian soldier in Gao who gave his name only as Sergeant Assak told Reuters during a pause in heavy gunfire around Independence Square.

Six Malian military pickups were deployed in the square and opened fire on the mayor's office with the heavy machineguns. Two injured soldiers were taken away in an ambulance.

French troops in armored vehicles later joined the battle as it spilled out into the warren of sandy streets, where, two weeks ago, they also fought for hours against Islamists who had infiltrated the town via the nearby river.

Helicopters clattered over the mayor's office, while a nearby local government office and petrol station was on fire.

A Gao resident said he heard an explosion and then saw a Malian military vehicle on fire in a nearby street.

Paris has said it plans to start withdrawing some of its 4,000 troops from Mali next month. But rebels have fought back against Mali's weak and divided army, and African forces due to take over the French role are not yet in place.

Islamists abandoned the main towns they held but French and Malian forces have said there are pockets of Islamist resistance across the north, which is about the size of France.

CAR BOMB

Residents reported a bomb in the east of Kidal on Thursday.

"It was a car bomb that exploded in a garage," said one resident who went to the scene but asked not to be named.

"The driver and another man were killed. Two other people were injured," he added.

A French defense ministry official confirmed there had been a car bomb but said it did not appear that French troops, based at the town's airport, had been targeted.

Earlier this week, a French soldier was killed in heavy fighting north of Kidal, where French and Chadian troops are hunting Islamists in the Adrar des Ifoghas mountains, which border Algeria.

Operations there are further complicated by the presence of separatist Tuareg rebels, whose rebellion triggered the fighting in northern Mali last year but were sidelined by the better-armed Islamists.

Having dispatched its forces to prevent an Islamist advance south in January, Paris is eager not to become bogged down in a long-term conflict in Mali. But their Malian and African allies have urged French troops not to pull out too soon.

(Additional reporting by Emanuel Braun in Gao, Adama Diarra in Bamako, David Lewis and John Irish in Dakar and Adrian Croft in Brussels; Writing by David Lewis; Editing by Jason Webb and Roger Atwood)

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New death from SARS-like virus in Saudi Arabia

GENEVA: Another person suffering from a SARS-like virus has died in Saudi Arabia, the World Health Organization said on Thursday, bringing the worldwide number of fatalities from the mystery illness to seven.

The Saudi health ministry informed the UN's health body that the patient had been hospitalised on January 29 and died on February 10, WHO said in a statement.

A laboratory had confirmed on February 18 that the person had died from the so-called novel coronavirus (NCoV), it added.

This brings the number of cases of the virus that have so far been reported to the WHO to 13. The virus was first detected in the middle of last year, with six previous fatalities -- three in Saudi Arabia, two in Jordan and one in Britain.

The news comes just days after a person suffering from the virus died in hospital in central England on Sunday.

That patient, who had a pre-existing health condition, was one of three people in the same family with the virus, which appeared to have been caught by one of the family members during a recent visit to the Middle East and Pakistan.

Even before the death in Britain, the WHO had on Saturday urged its member states to keep a close eye on any cases of severe acute respiratory infections, like pneumonia, and to "carefully review any unusual patterns."

Health authorities should test for NCoV in cases of unexplained pneumonia or other severe, "progressive or complicated respiratory illnesses not responding to treatment, particularly in persons travelling from or resident in areas of the world known to be affected," it said.

It also urged testing of any health workers showing such symptoms, and thorough investigations of clusters of cases, regardless of where they occur in the world.

WHO meanwhile did not recommend any travel or trade restriction in connection with the virus.

Coronaviruses cause most common colds but can also cause SARS (severe acute respiratory syndrome).

The new virus however is different from SARS, especially in that it causes rapid kidney failure.

A SARS epidemic killed more than 800 people when it swept out of China in 2003, sparking a major international health scare.

- AFP/fa

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Now, Jamiat divided over Narendra Modi

NEW DELHI: The Jamiat Ulema-Hind, which virtually controls the Islamic seminary Darul-Uloom at Deoband, appears sharply divided over Gujarat chief minister Narendra Modi.

Jamiat president Maulana Arshad Madni said on Thursday that there was no question of accepting the Gujarat strongman as India's prime minister. "Modi was wholly and solely responsible for the 2002 Gujarat riots. He is protecting and shielding many politicians who were directly involved in the worst communal riots in the country," he told the media.

A few days back, however, Malauna Mahmood Madni, general secretary of the Jamiat, came out with a tacit endorsement of Modi. "There is a change in the Muslim psyche towards Modi, and a section of Muslims voted for him in the recent assembly elections," he had said. "There is a perceptible change, and circumstances are different. Muslims in Gujarat are economically better off than in other states which have so-called secular governments."

Maulani Mahmood Madni, who rebelled against his uncle Maulana Arshad Madni four years back and floated a parallel group, said more innocents were languishing in jails in Maharashtra than in Gujarat.

Maulana Arshad Madni, however, insisted that in a secular country like India, there was no place for Modi. "I am sure and certain that the majority of the people reject his ideology. It is not only Muslims but also members of the majority community who oppose his communal agenda," he said.

Maulana Arshad Madni asked the government to reserve jobs for Muslims. He said the government should not take the support of minorities for granted.

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Flu shot doing a poor job of protecting elderly

ATLANTA (AP) — It turns out this year's flu shot is doing a startlingly dismal job of protecting senior citizens, the most vulnerable age group.

The vaccine is proving only 9 percent effective in people 65 and older against the harsh strain of the flu that is predominant this season, the Centers for Disease Control and Prevention said Thursday.

Health officials are baffled as to why this is so. But the findings help explain why so many older people have been hospitalized with the flu this year.

Despite the findings, the CDC stood by its recommendation that everyone over 6 months get flu shots, the elderly included, because some protection is better than none, and because those who are vaccinated and still get sick may suffer less severe symptoms.

"Year in and year out, the vaccine is the best protection we have," said CDC flu expert Dr. Joseph Bresee.

Overall, across the age groups studied, the vaccine's effectiveness was found to be a moderate 56 percent, which means those who got a shot have a 56 percent lower chance of winding up at the doctor with the flu. That is somewhat worse than what has been seen in other years.

For those 65 and older, the vaccine was only 27 percent effective against the three strains it is designed to protect against, the worst level in about a decade. It did a particularly poor job against the tough strain that is causing more than three-quarters of the illnesses this year.

It is well known that flu vaccine tends to protect younger people better than older ones. Elderly people have weaker immune systems that don't respond as well to flu shots, and they are more vulnerable to the illness and its complications, including pneumonia.

But health officials said they don't know why this year's vaccine did so poorly in that age group.

One theory, as yet unproven, is that older people's immune systems were accustomed to strains from the last two years and had more trouble switching gears to handle this year's different, harsh strain.

The preliminary data for senior citizens is less than definitive. It is based on fewer than 300 people scattered among five states.

But it will no doubt surprise many people that the effectiveness is that low, said Michael Osterholm, a University of Minnesota infectious-disease expert who has tried to draw attention to the need for a more effective flu vaccine.

Among infectious diseases, flu is considered one of the nation's leading killers. On average, about 24,000 Americans die each flu season, according to the CDC.

This flu season started in early December, a month earlier than usual, and peaked by the end of year. Hospitalization rates for people 65 and older have been some of the highest in a decade, at 146 per 100,000 people.

Flu viruses tend to mutate more quickly than others, so a new vaccine is formulated each year to target the strains expected to be the major threats. CDC officials have said that in formulating this year's vaccine, scientists accurately anticipated the strains that are circulating this season.

Because of the guesswork involved, scientists tend to set a lower bar for flu vaccine. While childhood vaccines against diseases like measles are expected to be 90 or 95 percent effective, a flu vaccine that's 60 to 70 percent effective in the U.S. is considered pretty good. By that standard, this year's vaccine is OK.

For senior citizens, a flu vaccine is considered pretty good if it's in the 30 to 40 percent range, said Dr. Arnold Monto, a University of Michigan flu expert.

A high-dose version of the flu shot was recently made available for those 65 and older, but the new study was too small to show whether that has made a difference.

The CDC estimates are based on about 2,700 people who got sick in December and January. The researchers traced back to see who had gotten shots and who hadn't. An earlier, smaller study put the vaccine's overall effectiveness at 62 percent, but other factors that might have influenced that figure weren't taken into account.

The CDC's Bresee said there is a danger in providing preliminary results because it may result in people doubting — or skipping — flu shots. But the figures were released to warn older people who got shots that they may still get sick and shouldn't ignore any serious flu-like symptoms, he said.

___

Online:

CDC report: http://www.cdc.gov/mmwr

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3 Dead in Rolling Gun Battle on Vegas Strip

A drive-by shooting on the Las Vegas strip early this morning by the occupants of a Range Rover SUV, who shot at the occupants of a Maserati, caused a multi-car accident and car explosion that left three dead.

Police said that they believe a group of men riding in a black Range Rover Sport SUV pulled up alongside a Maserati around 4:20 a.m. today and fired shots into the car, striking the driver and passenger, according to Officer Jose Hernandez of the Las Vegas Metropolitan police department.

The Maserati then swerved through an intersection, hitting at least four other cars. One car that was struck, a taxi with a driver and passenger in it, caught on fire and burst into flames, trapping both occupants, Hernandez said.

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The SUV then fled the scene, according to cops.

The driver of the Maserati died from his gunshot wounds at University Medical Center shortly after the shooting, according to Sgt. John Sheahan.

The driver and passenger of the taxi both died in the car fire.

At least three individuals, including the passenger of the Maserati, were injured during the shooting and car crashes and are being treated at UMC hospital.

Police are scouring surveillance video from the area, including from the strip's major casinos, to try and identify the Range Rover and its occupants, according to police.

They do not yet know why the Range Rovers' occupants fired shots at the Maserati or whether the cars had local plates or were from out of state.

No bystanders were hit by gunfire, Hernandez said.

"We're currently looking for a black Range Rover Sport, with large black rims and some sort of dealership advertising or advertisement plates," Hernandez said. "This is an armed and dangerous vehicle."

The Las Vegas Convention and Visitors Authority had no immediate comment about the safety of tourists in the wake of the shooting today.

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French general urges EU to equip "impoverished" Mali army

BAMAKO, Mali (Reuters) - The European Union should complement a mission to train Mali's army, routed by rebels last year, by providing equipment from uniforms to vehicles and communications technology, a French general said on Wednesday.

General Francois Lecointre, appointed to head the EU training mission to Mali (EUTM) that was formally launched this week, said in Bamako equipping the "very impoverished" and disorganized Malian army was as important as training it.

Europe, along with the United States, has backed the French-led military intervention in Mali which since January 11 has driven al Qaeda-allied Islamist insurgents out of the main northern towns into remote mountains near Algeria's border.

European governments have ruled out sending combat troops to join French and African soldiers pursuing the Islamist rebels.

But the EU is providing a 500-strong multinational training force that will give military instruction to Malian soldiers for an initial period of 15 months at an estimated cost of 12.3 million euros ($16.45 million).

While hailing what he called the EU's "courageous, novel, historic" decision to support Mali, Lecointre told a news conference the Malian army's lack of equipment was a problem.

"I know the Malian state is poor, but the Malian army is more than poor," the French general told a news conference, adding that it urgently needed everything from uniforms and weapons to vehicles and communications equipment.

Last year, when Tuareg separatist forces swelled by weapons and fighters from the Libyan conflict swept out of the northern deserts, a demoralized and poorly-led Malian army collapsed and fled before them, abandoning arms and vehicles.

Mali's military was further shaken by a March 22 coup by junior officers who toppled President Amadou Toumani Toure, sowing division among rival army factions. Islamist radicals allied to al Qaeda later hijacked the victorious Tuareg rebellion to occupy the northern half of the country.

In a fast-charging military campaign led by Paris, French and African troops have driven the jihadists out of principal northern towns like Gao and Timbuktu, and are fighting the rebels in the Adrar des Ifoghas mountains.

HUMAN RIGHTS INSTRUCTION

Flanked by Mali's armed forces chief, General Ibrahima Dembele, Lecointre said he was disappointed that a meeting of international donors last month pledged funds for an African military force, known as AFISMA, being deployed in Mali, but included "very few" contributions for the Malian army itself.

"The European Union needs to invest today in the equipping of the Malian army and not just in its training," the general said, adding he would make this point strongly in a report to EU member state representatives early next month.

Asked how much re-equipping the army would cost, he said it would be "much more" than the 12 million euros of EU financing for the training mission, but could not give a precise estimate.

Starting early in April, the EU mission will start instructing Malian soldiers with a plan to train four new battalions of 600-700 members each, formed from existing enlisted men and new recruits.

Lecointre said the EU training would include instruction in human rights. Demands for this increased after allegations by Malian civilians and international human rights groups that Malian soldiers were executing Tuaregs and Arabs accused of collaborating with Islamist rebels.

The European training contingent is drawn from a range of European countries, but the main contributors would be France, Germany, Italy, Spain and Britain, EUTM officers said.

Mali's army has received foreign training before - several battalions that fled before the rebels last year were trained by the U.S. military and the leader of the March 22 coup, Captain Amadou Sanogo, attended training courses in the United States.

Dembele said U.S. training failed to forge cohesion among Malian units and he hoped the EU training would achieve this.

The United States, which halted direct support for the Malian military after last year's coup, could eventually resume aid if planned national elections in July fully restore democracy to the West African country.

Washington is providing airlift, refuelling and intelligence support to the French-led military intervention in Mali. ($1 = 0.7479 euros)

(Reporting by Pascal Fletcher; Editing by Jason Webb)

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US stocks dive after Fed minutes

NEW YORK: US stocks piled up losses Wednesday after Federal Reserve minutes showed divisions over asset purchases, with some officials suggesting to wind them down before the jobs market picks up.

The Dow Jones Industrial Average finished down 108.13 points (0.77 percent) at 13,927.54.

The S&P 500-stock index fell 18.99 points (1.24 percent) to 1,511.95 and the tech-rich Nasdaq Composite dropped 49.18 points (1.53 percent) to 3,164.41, dragged down by heavyweight Apple, off 2.4 percent.

After opening mostly lower amid mixed housing and wholesale inflation data, the indexes hit fresh session lows after the Fed released the minutes of the January 29-30 Federal Open Market Committee meeting.

A "number" of participants said that an ongoing evaluation of the $85 billion per month asset purchases "might well lead the committee to taper or end its purchases before it judged that a substantial improvement in the outlook for the labor market had occurred," the minutes said.

Paul Edelstein of IHS Global Insight said in a research note that "if markets do not expect the Fed to stay the course, then expectations for economic growth and inflation will stay depressed and demand for safe assets (cash and government securities) will remain high."

Office Depot and OfficeMax meanwhile confirmed their merger after a premature announcement of the news.

The all-stock merger would create an $18 billion office supplies retailer. Office Depot shares slumped 16.7 percent and OfficeMax shed 7.0 percent.

Hotel chain Marriott fell 2.7 percent after posting quarterly results that missed expectations.

Luxury home builder Toll Brothers also suffered from disappointing earnings, losing 9.1 percent.

Dell, which reported a 32 percent profit fall in 2012 that was nevertheless slightly better than expected, rose 0.2 percent.

Yahoo! fell 1.7 percent after unveiling a new homepage.

Sony slid 1.2 percent ahead of its PlayStation 4 news conference

The bond market was mixed. The yield on the 10-year Treasury bond fell to 2.02 percent from 2.03 percent late Tuesday, while the 30-year edged up to 3.21 percent from 3.20 percent. Bond prices and yields move inversely.

-AFP/ac

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Trade unions' strike: Stick backfires, Mamata Banerjee offers carrot to traders

KOLKATA: Chastened by the widespread outrage among traders—who kept their shutters down despite her brandishing a stick, making Day One of the strike called by central trade unions a partial success—chief minister Mamata Banerjee decided to hand out carrots to the few who answered her call and kept their shops open on Wednesday.

Sources said Mamata asked mayor Sovon Chatterjee to work out an incentive to reward shop-owners who stayed open so that it encourages others to follow suit the next time. The decision was taken on the spur of the moment during an inspection of the city the CM undertook with the mayor in the early afternoon.

Mamata was initially taken aback at the sight of downed shutters in the wholesale belt of Burrabazar and Posta, but was relieved to see the vegetable market in Sealdah open.

Sources said the incentive idea struck her when she realized that cancelling the trade licences of those who stayed shut is not an option: the state will have to punish about 85% shopkeepers in the city then.

"I thank everyone who has opened their shop," Mamata said. "More shops are expected to open in the next half of the day. As for those that stayed shut, the high court has issued an order and the law will take its course."

Chatterjee said: "We are making a list of shops that were open. We will reward them." But officials in the Kolkata Municipal Corporation's licence department said there is no such rule and implementing the reward scheme will be difficult.

Mamata's decision to discuss the matter only with Forum of Traders' Organization (West Bengal) general secretary Rabindranath Koley boomeranged as other federations were aggrieved and did all they could to foil the government's efforts to keep shops open.

"Traders have shown politicians that they will not be scared into submission," said Tarak Trivedi of the Federation of Trade Organization that claims 50 lakh businessmen as members. "Treat us with respect and we will extend a helping hand."

On Tuesday, it was Koley who had announced the decision to take "uncooperative" traders to task. On Wednesday, he did the task of mollifying.

He said the CM is trying out various measures to lure traders away from the culture of staying at home during strikes. "In Kankurgachi, VIP, New Market, Gariahat, Lake Market and elsewhere, 50% shops were open," Koley said. "That is a long way from the scenes in the past when everything would be shut. The trading community is timid and needs to be encouraged to defy political strikes."

Timidity was, however, not the trait traders displayed when they defied the CM's threat of licence cancellation. "Had she called all the trade organizations and appealed to us to stay open, an overwhelming majority of shop-owners would have complied," said Atmaram Kajaria, president of the Federation of West Bengal Trade Association that claims to represent two crore traders in the state. "But by issuing a threat that is impractical and impossible to carry out, the CM suffered a loss of face that she could have easily avoided."

Though all trade unions, barring Citu, have decided to continue with the strike on Thursday, trade bodies said the scene will be different in Kolkata and most shops will open for business.

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