How Indian diplomacy ended crisis in Maldives

NEW DELHI: It was an "understanding" between India and Maldives that resolved an embarrassing political situation in the island country after former president Mohamed Nasheed took refuge inside the Indian high commission, drawing India into the heart of the ongoing political crisis there.

The resolution, which showcased Indian diplomacy at its most effective, confirmed India's position as the pre-eminent power in the Indian Ocean.

Both countries have denied there was a "deal", and there wasn't. Since the moment Nasheed became a refugee in the mission, India and Maldives and, after a while, even Nasheed himself, were looking for a way to end the agony.

On the Indian side, the initiative was led jointly by NSA Shivshankar Menon and foreign minister Salman Khurshid. Khurshid spoke with his counterpart Abdul Samad Abdulla several times in the past week to soften up the government there to the fact that a face-saving solution had to be found for all concerned.

Menon undertook the more complex job of directing the Indian effort, issuing instructions to the Indian team as well as keeping the larger picture of national interest in view. Foreign secretary Ranjan Mathai worked the phones with his counterpart and other leaders in Male from Washington DC where he was travelling. But it was the low-key actions of Harsh Vardhan Shringla, joint secretary in the ministry of external affairs, that finally won the day in Male.

Shringla and his team met an entire cross-section of the Maldives leadership — defence minister Mohamed Nazim, foreign minister Abdul Samad Abdulla, attorney general Aishath Azima Shakoor, even Abdulla Yamin, leader of the Progressive Party of Maldives (Gayoom's party), as well as acting foreign secretary Abdul Azeez Yoosuf, among others. The mission was two-fold — first to convince them that India had no role to play in the political crisis.

Second, to make sure that the election process in Maldives had the field open for all candidates.

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FDA approves new targeted breast cancer drug

WASHINGTON (AP) — The Food and Drug Administration has approved a first-of-a-kind breast cancer medication that targets tumor cells while sparing healthy ones.

The drug Kadcyla from Roche combines the established drug Herceptin with a powerful chemotherapy drug and a third chemical linking the medicines together. The chemical keeps the cocktail intact until it binds to a cancer cell, delivering a potent dose of anti-tumor poison.

Cancer researchers say the drug is an important step forward because it delivers more medication while reducing the unpleasant side effects of chemotherapy.

"This antibody goes seeking out the tumor cells, gets internalized and then explodes them from within. So it's very kind and gentle on the patients — there's no hair loss, no nausea, no vomiting," said Dr. Melody Cobleigh of Rush University Medical Center. "It's a revolutionary way of treating cancer."

Cobleigh helped conduct the key studies of the drug at the Chicago facility.

The FDA approved the new treatment for about 20 percent of breast cancer patients with a form of the disease that is typically more aggressive and less responsive to hormone therapy. These patients have tumors that overproduce a protein known as HER-2. Breast cancer is the second most deadly form of cancer in U.S. women, and is expected to kill more than 39,000 Americans this year, according to the National Cancer Institute.

The approval will help Roche's Genentech unit build on the blockbuster success of Herceptin, which has long dominated the breast cancer marketplace. The drug had sales of roughly $6 billion last year.

Genentech said Friday that Kadcyla will cost $9,800 per month, compared to $4,500 per month for regular Herceptin. The company estimates a full course of Kadcyla, about nine months of medicine, will cost $94,000.

FDA scientists said they approved the drug based on company studies showing Kadcyla delayed the progression of breast cancer by several months. Researchers reported last year that patients treated with the drug lived 9.6 months before death or the spread of their disease, compared with a little more than six months for patients treated with two other standard drugs, Tykerb and Xeloda.

Overall, patients taking Kadcyla lived about 2.6 years, compared with 2 years for patients taking the other drugs.

FDA specifically approved the drug for patients with advanced breast cancer who have already been treated with Herceptin and taxane, a widely used chemotherapy drug. Doctors are not required to follow FDA prescribing guidelines, and cancer researchers say the drug could have great potential in patients with earlier forms of breast cancer

Kadcyla will carry a boxed warning, the most severe type, alerting doctors and patients that the drug can cause liver toxicity, heart problems and potentially death. The drug can also cause severe birth defects and should not be used by pregnant women.

Kadcyla was developed by South San Francisco-based Genentech using drug-binding technology licensed from Waltham, Mass.-based ImmunoGen. The company developed the chemical that keeps the drug cocktail together and is scheduled to receive a $10.5 million payment from Genentech on the FDA decision. The company will also receive additional royalties on the drug's sales.

Shares of ImmunoGen Inc. rose 2 cents to $14.32 in afternoon trading. The stock has ttraded in a 52-wek range of $10.85 to $18.10.

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NASCAR: Daytona Race to Go On After Crash

Every seat will be filled at Daytona International Speedway today after a team worked overnight to repair a fence that was breached in a horrific crash that injured at least 28 spectators in the grandstands.

Joie Chitwood III, president of Daytona International Speedway, said his team met with NASCAR officials at 8 a.m. EST today to review the repairs, hours before 147,000 fans will fill the grandstand seats to watch the Daytona 500 race.

If fans are uneasy about their seating location today, Chitwood said his team would make "every accommodation we can" to move them.

PHOTOS: Crash at Daytona Sends Wreckage Into Stands

The track became a disaster scene on Saturday when 12 cars became tangled in a fiery crash during the final lap of the Nationwide race.

Pieces of rookie Kyle Larson's shredded race car turned into shrapnel that flew into the stands, injuring at least 28 people.

Chris Graythen/Getty Images

RELATED: Fiery Daytona Crash Injures Fans

At least 14 of the injured were transported to hospitals and more than a dozen others were treated at the speedway, Chitwood said.

"I do know that we transported individuals from lower level and upper level [of the grandstands]," he said.

Terry Huckabee, who was sitting in the grandstands with his brother, compared the scene to a "war zone."

"I mean, tire flying by and smoke and everything else," he said.

Huckabee said his brother is recovering in the hospital after his leg was sliced open by the spray of debris.

The crash was apparently triggered when driver Regan Smith's car, which was being tailed by Brad Keselowski on his back bumper, spun to the right and shot up the track.

Smith had been in the lead and said after the crash he had been trying to throw a "block."

Larson's car slammed into the wall that separates the track from the grandstands, causing his No. 32 car to go airborne and erupt in flames.

When a haze of smoke cleared and Larson's car came to a stop, he jumped out uninjured.

His engine and one of his wheels were sitting in a walkway of the grandstand.

"I was getting pushed from behind," Larson told ESPN. "Before I could react, it was too late."

Tony Stewart pulled out the win, but in victory lane, what would have been a celebratory mood was tempered by concern for the injured fans.

"We've always known this is a dangerous sport," Stewart said. "But it's hard when the fans get caught up in it."

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Tens of thousands in Spain protest economic policy, corruption

MADRID (Reuters) - Tens of thousands of Spaniards marched through cities across the country on Saturday to protest deep austerity, the privatization of public services and political corruption.

Gathering under the banner of the "Citizen Tide", students, doctors, unionists, young families and pensioners staged rowdy but non-violent demonstrations as a near five-year economic slump shows no sign of recovery and mass unemployment rises.

"I'm here to add my voice. They're cutting where they shouldn't cut; health, education ... basic services. And the latest corruption scandal is just the tiniest tip of a very large iceberg," said Alberto, 51, an account administrator for a German multinational in Madrid, who preferred not to give his surname.

Protests in Spain have become commonplace as the conservative government passes measures aimed at shrinking one of the euro zone's highest budget deficits and reinventing an economy hobbled by a burst housing bubble.

Prime Minister Mariano Rajoy has introduced some of the deepest budget cuts in Spain's democratic history in an attempt to convince investors the country can weather the economic crisis without falling back on international aid.

But, with more than half of the country's young people out of work and growth not expected until sometime next year, the measures have only scratched the surface of the budget shortfall which is expected to be more than double the target in 2014.

Meanwhile, corruption scandals which have hit the ruling party as well as the once-popular royal family has left many Spaniards disenchanted with their leaders on all sides of the political spectrum.

In Madrid, under a clear, cold winter sky, Saturday's marches convened from four different points by early evening in Neptune Square, between the heavily policed and barricaded parliament, the Ritz Hotel and the stock exchange.

Carrying placards which condemned everything from cuts in the health sector to massive bailouts granted to Spain's banking system, crowds banged drums and chanted, while dozens of riot police stood on the sidelines.

The march coincided with the anniversary of a failed coup attempt in 1981 by Civil Guard officers who stormed Parliament and held deputies hostage until the next day.

(Reporting By Paul Day; Editing by Jason Webb)

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Ecuador president vows to push large-scale mining

QUITO: Ecuador's re-elected President Rafael Correa said Saturday he will push large-scale mining projects during his next four years in office, despite opposition from some indigenous groups.

"The Ecuadoran people have voted to responsibly take advantage of non-renewable resources," said in a weekly address on his administration's activities.

Correa, a socialist, said his goal was to use the country's mining and oil wealth to eliminate poverty and said he was committed to "the Amazonian people and all the areas where there is mining or oil."

A year ago, Correa's government signed a contract with the Chinese company Ecuacorriente to mine copper in the Amazon basin province of Zamora-Chinchipe, in a major move to open the country to large-scale mining.

The country's largest indigenous organisation opposed the deal, however, and with the backing of opposition groups led a two-week-long protest march from the Amazon to Quito.

But Correa, who has been in power since 2007, won re-election last week in a landslide, with 56.77 per cent of the vote, and he used his speech Saturday to criticise opponents of big mining.

"To hurt the government, they are hurting the country, the poor, that Amazonian region," Correa said, adding that "we are not with the multinationals, we are with the poor."

"We cannot be beggars sitting in front of a bag of gold," he said.

- AFP/jc

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Plaint against Baba Ramdev for slamming Gandhis

BELGAUM: A complaint has been registered against yoga guru Baba Ramdev in the fourth JMF Court for allegedly making derogatory statements against AICC president Sonia Gandhi and vice-president Rahul Gandhi.

Former KPCC member Shankar Munavalli filed the case. In a complaint, he alleged that Baba Ramdev, during his visit to Hubli on February 20, said that corruption had increased in the country because "AICC president Sonia Gandhi and his son Rahul were exporting money to Italy".

He also said that both should be expelled from the country, if the country has to become free from corruption. Munavalli claimed that Ramdev deliberately attempted to defame the image of Sonia and Rahul Gandhi without any evidence.

Besides, no complaint had been filed in any court on them as alleged by Ramdev. Munavalli urged action against the yoga guru, saying that his statement hurt the sentiments of Congress party workers.

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FDA approves new targeted breast cancer drug

WASHINGTON (AP) — The Food and Drug Administration has approved a first-of-a-kind breast cancer medication that targets tumor cells while sparing healthy ones.

The drug Kadcyla from Roche combines the established drug Herceptin with a powerful chemotherapy drug and a third chemical linking the medicines together. The chemical keeps the cocktail intact until it binds to a cancer cell, delivering a potent dose of anti-tumor poison.

Cancer researchers say the drug is an important step forward because it delivers more medication while reducing the unpleasant side effects of chemotherapy.

"This antibody goes seeking out the tumor cells, gets internalized and then explodes them from within. So it's very kind and gentle on the patients — there's no hair loss, no nausea, no vomiting," said Dr. Melody Cobleigh of Rush University Medical Center. "It's a revolutionary way of treating cancer."

Cobleigh helped conduct the key studies of the drug at the Chicago facility.

The FDA approved the new treatment for about 20 percent of breast cancer patients with a form of the disease that is typically more aggressive and less responsive to hormone therapy. These patients have tumors that overproduce a protein known as HER-2. Breast cancer is the second most deadly form of cancer in U.S. women, and is expected to kill more than 39,000 Americans this year, according to the National Cancer Institute.

The approval will help Roche's Genentech unit build on the blockbuster success of Herceptin, which has long dominated the breast cancer marketplace. The drug had sales of roughly $6 billion last year.

Genentech said Friday that Kadcyla will cost $9,800 per month, compared to $4,500 per month for regular Herceptin. The company estimates a full course of Kadcyla, about nine months of medicine, will cost $94,000.

FDA scientists said they approved the drug based on company studies showing Kadcyla delayed the progression of breast cancer by several months. Researchers reported last year that patients treated with the drug lived 9.6 months before death or the spread of their disease, compared with a little more than six months for patients treated with two other standard drugs, Tykerb and Xeloda.

Overall, patients taking Kadcyla lived about 2.6 years, compared with 2 years for patients taking the other drugs.

FDA specifically approved the drug for patients with advanced breast cancer who have already been treated with Herceptin and taxane, a widely used chemotherapy drug. Doctors are not required to follow FDA prescribing guidelines, and cancer researchers say the drug could have great potential in patients with earlier forms of breast cancer

Kadcyla will carry a boxed warning, the most severe type, alerting doctors and patients that the drug can cause liver toxicity, heart problems and potentially death. The drug can also cause severe birth defects and should not be used by pregnant women.

Kadcyla was developed by South San Francisco-based Genentech using drug-binding technology licensed from Waltham, Mass.-based ImmunoGen. The company developed the chemical that keeps the drug cocktail together and is scheduled to receive a $10.5 million payment from Genentech on the FDA decision. The company will also receive additional royalties on the drug's sales.

Shares of ImmunoGen Inc. rose 2 cents to $14.32 in afternoon trading. The stock has ttraded in a 52-wek range of $10.85 to $18.10.

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Pistorius Family: 'Law Must Run Its Course'

South African Olympian Oscar Pistorius is spending time his family today after the athlete was freed on $113,000 bail Friday.

"We realise that the law must run its course, and we would not have it any other way," the Olympian's uncle, Arnold Pistorius said in a statement on Saturday.

The Pistorius family expressed their gratitude that the former Olympian was allowed out of jail before the trial.

"This constitutes a moment of relief under these otherwise very grave circumstances" said Arnold Pistorius."We are extremely thankful that Oscar is now home."

Pistorius, 26, is charged with premeditated murder in the Valentine's Day shooting of his girlfriend Reeva Steenkamp.

While the prosecution argued that the world-renowned athlete was a flight risk and had a history of violence, South African Magistrate Desmond Nair, who presided over the case, disagreed.

FULL COVERAGE: Oscar Pistorius

"He regards South Africa as his permanent place of abode, he has no intention to relocate to any other country" Nair said during his two hour ruling, before concluding with, "the accused has made the case to be released on bail."

'Blade Runner' Murder Charges: Oscar Pistorius Out on Bail Watch Video

Oscar Pistorius Granted Bail in Murder Case Watch Video

Pistoriuis will have to adhere to strict conditions to stay out of jail before the trial. He must give up all his guns, he cannot drink alcohol or return to the home where the shooting occurred, and he must check in with a police department twice a week.

Oscar Pistorius is believed to be staying at an uncle's house as he awaits trial.

RELATED: Oscar Pistorius Case: Key Elements to the Murder Investigation

During the hearing, the prosecution argued that Pistorius shot Steenkamp after an argument, while the defense laid out an alternate version of events saying Pistorius mistook his girlfriend for an intruder.

Nair took issue with the head detective originally in charge of the case, who he said "blundered" in gathering evidence and was removed from the case after it was revealed he is facing attempted murder charges.

RELATED: Oscar Pistorius Case: Lead Det. Hilton Botha to Be Booted From Investigation Team

After the magistrate's decision, cheers erupted in the courtroom from the Pistorius camp. Pistorius' trial is expected to start in six to eight months, with his next pre-trial court date in June.

Reeva Steenkamp Family Reaction

Steenkamp's father, Barry Steenkamp told the South African Beeld newspaper that the 26-year-old athlete will "suffer" if he is lying about accidentally shooting 29-year-old model.

PHOTOS: Oscar Pistorius Charged with Murder

Barry Steenkamp went on to say that the Pistorius will have to "live with his conscience" if he intentionally shot Reeva.

The Associated Press contributed to this report.

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Rockets hit Aleppo, killing at least 29: monitor

BEIRUT (Reuters) - Rockets struck eastern districts of Aleppo, Syria's biggest city, on Friday, killing at least 29 people and trapping a family of 10 in the ruins of their home, activists in the city said.

"There are families buried under the rubble," said an activist called Baraa al-Youssef, speaking by Skype after visiting the scene in his Ard al-Hamra neighborhood.

"Nothing can describe it, it's a horrible sight."

Video footage posted by several activists showed a burning building and people carrying the wounded to cars to be ferried to hospital. It was hard to gauge the scale of the damage in the night-time footage but rubble was clearly visible on the ground.

Rami Abdulrahman of the British-based Syrian Observatory for Human Rights said three explosions shook Aleppo and reported at least 29 people had been killed. Another 150 were wounded, he said, and the final death toll was likely to be higher.

Youssef said 30 houses were destroyed by a single rocket.

On Tuesday activists said at least 20 people were killed when a large missile of the same type as Russian-made Scuds hit the rebel-held district of Jabal Badro.

(Reporting by Mariam Karouny and Dominic Evans; Editing by Stephen Powell)

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Catholic priests should be able to marry: British cardinal

LONDON: Roman Catholic priests should be able to marry and have children, Britain's most senior cardinal said on Friday.

Cardinal Keith O'Brien, who will be part of the conclave tasked with choosing a new pope to replace Benedict XVI, said the church's requirement for priests to be celibate was not of "divine origin" and should be reconsidered.

"Many priests have found it very difficult to cope with celibacy as they lived out their priesthood, and felt the need of a companion, of a woman, to whom they could get married and raise a family of their own," the 74-year-old told the BBC.

"The celibacy of the clergy, whether priests should marry -- Jesus didn't say that.

"There was a time when priests got married, and of course we know at the present time in some branches of the church -- in some branches of the Catholic church -- priests can get married," he added.

"So that is obviously not of divine origin and it could get discussed again."

O'Brien will have a say in who succeeds Benedict after he stands down on February 28.

He said he had not yet decided who should take over leadership of the world's 1.2 billion Catholics, but suggested it could be time for a younger pontiff, possibly from the developing world.

"I would be open to a pope from anywhere if I thought it was the right man, whether it was Europe or Asia or Africa or wherever," he added.

Benedict stunned the world last week by becoming the first pope in more than 700 years to resign voluntarily.

No clear favourite has emerged, although the 85-year-old's announcement that he lacked the strength to lead the church indicates the need for a younger pope.

- AFP/jc

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