Lack of sleep leads to groggy genes: study






WASHINGTON: Lack of sleep has a potentially harmful effect on gene expression, according to a study out Tuesday that sheds light on the link between sleep deficits and a wide range of health conditions.

A sleep deficit -- even just a week's worth -- can have damaging effects on our genes, researchers said in a new study out Tuesday.

Lack of adequate shut-eye had already been linked to conditions from heart disease and cognitive impairment to obesity.

But sleep researcher Derk-Jan Dijk and his fellow researchers have delved into the molecular mechanisms behind the phenomenon, looking at how missed sleep leads to health problems.

They found that a week of sleeping six hours or less a night affects the expression of some 711 genes -- including those involved in inflammation, immunity, and stress responses.

Moreover, compared with test subjects who were allowed to sleep as long as 10 hours a night, those who lacked sleep had irregularities in their genes' circadian rhythms, experiencing a sharp reduction in the number of genes that wax and wane throughout the day and a dampened amplitude for many more.

At the end of the week, the test subjects were kept awake for 40 hours, with blood tests at regular intervals.

The research showed that, for those who had gotten adequate sleep previously, the affects of the sleep deprivation were seven times less than for those already operating under a sleep deficit.

Nearly a third of American workers -- some 40.6 million people -- average six hours or less of sleep a night, according to a 2010 study by the Centers for Disease Control and Prevention.

A normal night's sleep for healthy adults is considered to be between seven and eight hours.

-AFP/ac



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IB sulks over govt bid to place NCTC outside its ambit

NEW DELHI: As it tries to assuage the concerns of states over the National Counter Terrorism Centre (NCTC), which sees the concept as an encroachment on their turf, now the Centre also has to contend with the resentment of the Intelligence Bureau (IB) to the proposed mechanism.

Anxious to win over the states on the issue of NCTC which it sees as imperative for better co-ordination among counter-terror agencies, the Centre is considering keeping the proposed body out IB's ambit. States had apprehended that NCTC being part of the IB will help the Centre extend its jurisdiction to "law and order" issues which under the Constitution is not part of New Delhi's remit. The Centre has tried to appease states also by proposing that NCTC will be mandated not to carry out arrests of terror suspect in any state without informing the relevant DGP.

While the response of states to the fresh NCTC pitch is still awaited, the Centre has to put up with the sulks of IB. The leading intelligence body had seethed with resentment when the government responded to the trauma of 26/11 attack on Mumbai by setting up the National Investigating Agency (NIA). The arrival of NIA, with a countrywide jurisdiction that other central agencies can only envy, has been at the cost of IB's reputation as government's chief counter-terror agency.

The fear of loss has also fuelled anxiety about what the setting up of NCTC might spell for the IB. Sources in the home ministry said that concept of NCTC as the premier body tasked with gathering and disseminating counter-terror intelligence, which will be functioning independently of the IB, will be a blow to what a MHA source called "the Old Lady".

As per a Cabinet note prepared by the MHA for consideration by the Cabinet Committee on Security (CCS) at its next meeting, the NCTC has been proposed as an independent body reporting directly to the Union home secretary. Its chief will now be a DGP-level officer, as against the additional DGP-rank proposed earlier: a change that can only add to the autonomy of the body vis-a-vis the IB.

The Cabinet note also seeks to revise the norms for exercising NCTC's powers of search and arrest during operations, and makes it mandatory for the body to inform the DGP of the state concerned, in advance.

According to sources in the government, the IB, in its comments on the CCS note, does not agree with the proposal to take NCTC out of its ambit and make it a parallel organization under the MHA. A senior government functionary indicated that the IB has even opposed powers of search and arrest for NCTC, stating that these should remain with the state governments or the NIA.

There is also a view that NCTC can be placed under NIA, as it would then automatically be empowered to search and arrest as per the NIA Act. A senior NIA official said creating a separate counter-terror body would pose practical problems like getting good officers on deputation and other infrastructure, something that has been ailing NIA as well.

The fresh thrust for operationalizing NCTC, created by an executive order passed in February, 2012, comes in the wake of the Hyderabad blasts pointing to gaps in intelligence coordination between the Centre and the states. Though both the Opposition as well as state governments agree on the basic need to have a specialized counter-terror body at the Centre, they are opposing NCTC in its current avatar.

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C. Everett Koop, 'rock star' surgeon general, dies


NEW YORK (AP) — Dr. C. Everett Koop has long been regarded as the nation's doctor— even though it has been nearly a quarter-century since he was surgeon general.


Koop, who died Monday at his home in Hanover, N.H., at age 96, was by far the best known and most influential person to carry that title. Koop, a 6-foot-1 evangelical Presbyterian with a biblical prophet's beard, donned a public health uniform in the early 1980s and became an enduring, science-based national spokesman on health issues.


He served for eight years during the Reagan administration and was a breed apart from his political bosses. He thundered about the evils of tobacco companies during a multiyear campaign to drive down smoking rates, and he became the government's spokesman on AIDS when it was still considered a "gay disease" by much of the public.


"He really changed the national conversation, and he showed real courage in pursuing the duties of his job," said Chris Collins, a vice president of amfAR, the Foundation for AIDS Research.


Even before that, he had been a leading figure in medicine. He was one of the first U.S. doctors to specialize in pediatric surgery at a time when children with complicated conditions were often simply written off as untreatable. In the 1950s, he drew national headlines for innovative surgeries such as separating conjoined twins.


His medical heroics are well noted, but he may be better remembered for transforming from a pariah in the eyes of the public health community into a remarkable servant who elevated the influence of the surgeon general — if only temporarily.


"He set the bar high for all who followed in his footsteps," said Dr. Richard Carmona, who served as surgeon general a decade later under President George W. Bush.


Koop's religious beliefs grew after the 1968 death of his son David in a mountain-climbing accident, and he became an outspoken opponent of abortion. His activism is what brought him to the attention of the administration of President Ronald Reagan, who decided to nominate him for surgeon general in 1981. Though once a position with real power, surgeon generals had been stripped of most of their responsibilities in the 1960s.


By the time Koop got the job, the position was kind of a glorified health educator.


But Koop ran with it. One of his early steps involved the admiral's uniform that is bestowed to the surgeon general but that Koop's predecessors had worn only on ceremonial occasions. In his first year in the post, Koop stopped wearing his trademark bowties and suit jackets and instead began wearing the uniform, seeing it as a way to raise the visual prestige of the office.


In those military suits, he surprised the officials who had appointed him by setting aside his religious beliefs and feelings about abortion and instead waging a series of science-based public health crusades.


He was arguably most effective on smoking. He issued a series of reports that detailed the dangers of tobacco smoke, and in speeches began calling for a smoke-free society by the year 2000. He didn't get his wish, but smoking rates did drop from 38 percent to 27 percent while he was in office — a huge decline.


Koop led other groundbreaking initiatives, but perhaps none is better remembered than his work on AIDS.


The disease was first identified in 1981, before Koop was officially in office, and it changed U.S. society. It destroyed the body's immune system and led to ghastly death, but initially was identified in gay men, and many people thought of it as something most heterosexuals didn't have to worry about.


U.S. scientists worked hard to identify the virus and work on ways to fight it, but the government's health education and policy efforts moved far more slowly. Reagan for years was silent on the issue. Following mounting criticism, Reagan in 1986 asked Koop to prepare a report on AIDS for the American public.


His report, released later that year, stressed that AIDS was a threat to all Americans and called for wider use of condoms and more comprehensive sex education, as early as the third grade. He went on to speak frankly about AIDS in an HBO special and engineered the mailing of an educational pamphlet on AIDS to more than 100 million U.S. households in 1988.


Koop personally opposed homosexuality and believed sex should be saved for marriage. But he insisted that Americans, especially young people, must not die because they were deprived of explicit information about how HIV was transmitted.


Koop's speeches and empathetic approach made him a hero to a wide swath of America, including public health workers, gay activists and journalists. Some called him a "scientific Bruce Springsteen." AIDS activists chanted "Koop, Koop" at his appearances and booed other officials.


"I was walking down the street with him one time" about five years ago, recalled Dr. George Wohlreich, director of the College of Physicians of Philadelphia, a medical society with which Koop had longstanding ties. "People were yelling out, 'There goes Dr. Koop!' You'd have thought he was a rock star."


Koop angered conservatives by refusing to issue a report requested by the Reagan White House, saying he could not find enough scientific evidence to determine whether abortion has harmful psychological effects on women.


He got static from some staff at the White House for his actions, but Reagan himself never tried to silence Koop. At a congressional hearing in 2007, Koop spoke about political pressure on the surgeon general post. He said Reagan was pressed to fire him every day.


After his death was reported Monday, the tributes poured forth, including a statement from New York Mayor Michael Bloomberg, who has made smoking restrictions a hallmark of his tenure.


"The nation has lost a visionary public health leader today with the passing of former Surgeon General C. Everett Koop, who was born and raised in Brooklyn," Bloomberg said. "Outspoken on the dangers of smoking, his leadership led to stronger warning labels on cigarettes and increased awareness about second-hand smoke, creating an environment that helped millions of Americans to stop smoking — and setting the stage for the dramatic changes in smoking laws that have occurred over the past decade."


Dr. Anthony Fauci of the National Institutes of Health taught Koop what was known about AIDS during quiet after-hours talks in the early 1980s and became a close friend.


"A less strong person would have bent under the pressure," Fauci said. "He was driven by what's the right thing to do."


Carmona, a surgeon general years later, said Koop was a mentor who preached the importance of staying true to the science in speeches and reports — even when it made certain politicians uncomfortable.


"We remember him for the example he set for all of us," Carmona said.


Koop's nomination originally was met with staunch opposition. Women's groups and liberal politicians complained Reagan had selected him only because of his conservative views, especially his staunch opposition to abortion.


Foes noted that Koop traveled the country in 1979 and 1980 giving speeches that predicted a progression "from liberalized abortion to infanticide to passive euthanasia to active euthanasia, indeed to the very beginnings of the political climate that led to Auschwitz, Dachau and Belsen."


But Koop, a devout Presbyterian, was confirmed as surgeon general after he told a Senate panel he would not use the post to promote his religious ideology. He kept his word and eventually won wide respect with his blend of old-fashioned values, pragmatism and empathy.


Koop was modest about his accomplishments, saying before leaving office in 1989, "My only influence was through moral suasion."


The office declined after that. Few of his successors had his speaking ability or stage presence. Fewer still were able to secure the support of key political bosses and overcome the meddling of everyone else. The office gradually lost prestige and visibility, and now has come to a point where most people can't name the current surgeon general. (It's Dr. Regina Benjamin.)


Even after leaving office, Koop continued to promote public health causes, from preventing childhood accidents to better training for doctors.


"I will use the written word, the spoken word and whatever I can in the electronic media to deliver health messages to this country as long as people will listen," he promised.


In 1996, he rapped Republican presidential hopeful Bob Dole for suggesting that tobacco was not invariably addictive, saying Dole's comments "either exposed his abysmal lack of knowledge of nicotine addiction or his blind support of the tobacco industry."


He maintained his personal opposition to abortion. After he left office, he told medical students it violated their Hippocratic oath. In 2009, he wrote to Senate Majority Leader Harry Reid, urging that health care legislation include a provision to ensure doctors and medical students would not be forced to perform abortions. The letter briefly set off a security scare because it was hand delivered.


Koop served as chairman of the National Safe Kids Campaign and as an adviser to President Bill Clinton's health care reform plan.


Worried that medicine had lost old-fashioned caring and personal relationships between doctors and patients, Koop opened an institute at Dartmouth College in New Hampshire to teach medical students basic values and ethics. He also was a part-owner of a short-lived venture, drkoop.com, to provide consumer health care information via the Internet.


Koop was the only son of a Manhattan banker and the nephew of a doctor. He said by age 5 he knew he wanted to be a surgeon and at age 13 he practiced his skills on neighborhood cats. He attended Dartmouth, where he received the nickname Chick, short for "chicken Koop." It stuck for life.


He received his medical degree at Cornell Medical College, choosing pediatric surgery because so few surgeons practiced it. In 1938, he married Elizabeth Flanagan, the daughter of a Connecticut doctor. They had four children. Koop's wife died in 2007, and he married Cora Hogue in 2010.


He was appointed surgeon-in-chief at Children's Hospital in Philadelphia and served as a professor at the University of Pennsylvania School of Medicine. He pioneered surgery on newborns and successfully separated three sets of conjoined twins. He won national acclaim by reconstructing the chest of a baby born with the heart outside the body.


Although raised as a Baptist, he was drawn to a Presbyterian church near the hospital, where he developed an abiding faith. He began praying at the bedside of his young patients — ignoring the snickers of some of his colleagues.


___


Contributing to this report were Associated Press writers Wilson Ring in Montpelier, Vt.; Jeff McMillan in Philadelphia; and AP Medical Writer Lauran Neergaard in Washington.


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'93 WTC Bombing Crushed Lives, Not Memories












Edward Smith remembers vividly the call from the morgue 20 years ago today, that his pregnant wife had died in the World Trade Center bombing hours before she was supposed to start her maternity leave.


"It seems like kind of yesterday sometimes," he told ABC News, "but it seems like a long time ago, too."


Today marks the 20th anniversary of the 1993 WTC bombing, which was overshadowed eight years later by the 9/11 attacks. Six people died and about 1,000 were injured after terrorists detonated a truck bomb in the parking garage of the World Trade Center's North Tower Feb. 26, 1993.


Four of the six killed -- Robert Kirkpatrick, 61, Stephen A. Knapp, 47, William Macko, 57, and Monica Rodriguez Smith, 35 -- were employees of the Port Authority of New York and New Jersey, which owned the buildings. John DiGiovanni, 45, a dental-supply salesman visiting the World Trade Center, and Wilfredo Mercado, 37, a purchasing agent for Windows on the World restaurant, also died.


To commemorate the event, ABC News spoke with several people affected by the bombing -- a widower, a former Port Authority executive director, a plaintiff's attorney and a jury foreman -- to illustrate how the bombing resonates 20 years later.


EDWARD SMITH: Husband of pregnant Monica Rodriguez Smith, who died in the bombing.



Edward and Monica Rodriguez Smith on their wedding day, Aug. 31, 1990.










September 11: World Trade Center Time Lapse Watch Video







Edward Smith, 50, remembers where he was Feb. 26, 1993, when he heard the news.


"I was up in Boston, and I had heard there was a fire at the [World] Trade Center," Smith told ABCNews.com last week. "I turned the TV on, and eventually heard there was an actual bombing, and drove down as quickly as I could."


Smith said he couldn't reach his wife, Monica Rodriguez Smith, a secretary for a mechanical supervisor for the Port Authority of New York and New Jersey who worked in the World Trade Center, for "hours and hours."


He said he didn't hear from her or anything about her until he contacted the New York City morgue at 11:30 p.m. that evening.


"Obviously, I was informed that I should come there," Smith said.


He and his wife had been married for a little more than three years, he said, and Feb. 26 was to be Monica's last day of work before she went on maternity leave. They were expecting their first child, a boy, to be named Eddie.


"She had worked at the Port Authority for at least 12 years," Smith said. "And she had just gotten an award for never having a sick day. That was a little thing you remember."


Smith said the World Trade Center was where he met his wife the first time.


"I was a sales guy, selling to the Port Authority, and she was the admin [secretary] for one of the guys," he said. "For the first two years, she wouldn't go out with me.


"She said, 'Do you know how many knuckleheads come in here and ask me out? What makes you different?'" Smith recalled Monica's saying.


It took her two years to go out on a date with him, Smith said.


The couple tied the knot Aug. 31, 1990. Smith said he even bought the house in which he grew up on Long Island to raise their family.


But after the events of Feb. 26, 1993, Smith said, it was hard to stay in New York. Shortly after the bombing, he moved to Arizona and later to California.


"There were too many reminders, it was too much," he said.


Smith now resides in Phoenix, but makes a trip to New York every year for the memorial in February.
This year is no exception.


"It's kind of an interesting feeling," he said of the 20-year anniversary. "It seems like kind of yesterday sometimes, but it seems like a long time ago, too."






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Football: Brilliant Bale shines again as Spurs edge thriller






LONDON: Gareth Bale fired Tottenham into third place in the Premier League as his sublime last minute goal capped a majestic performance in a 3-2 win over West Ham at Upton Park on Monday.

Bale has been in the form of his life in recent weeks and the Wales winger added another chapter to his growing legend with a brilliant brace that would surely have been appreciated by Hammers legend Bobby Moore, whose death 20 years ago was marked by a moving pre-match tribute.

Moore, regarded as one of the best defenders in the history of the game, famously captained England to World Cup glory in 1966 and also led West Ham to FA Cup and Cup Winners' Cup triumphs.

But even Moore might have been hard pressed to subdue Bale in this mood.

Bale had given Spurs a first half lead but an Andy Carroll penalty and Joe Cole's strike put West Ham ahead by the hour mark.

Gylfi Sigurdsson came off the bench to equalise and Bale produced a simply remarkable long-range winner to move Tottenham, unbeaten in their last 11 league games, two points clear of Chelsea and four ahead of fifth placed Arsenal, who visit White Hart Lane on Sunday.

"Gareth Bale is unbelievable, a super talent. We have seen him at another level this season," Spurs manager Andre Villas-Boas said.

"He makes the difference in every single game. Players like this assume responsibility at key moments. When you see him joyful on the pitch he gives you rewards.

"The gap to second place is not big and we have a chance to put Arsenal away on Sunday."

Bale added: "It's not about me, it's about the team and we played really well.

"We obviously wanted to get the three points to keep our Champions League hopes alive."

Bale underlined his claims as the best player in the Premier League with yet another moment of magic to put Spurs ahead in the 13th minute.

He was surrounded by West Ham defenders on the edge of the penalty area, but, drifting away from James Collins, he cleverly worked space for a shot and as West Ham's back-four hesitated the Welsh winger drove a low strike past Jussi Jaaskelainen.

That was Bale's 22nd goal for club and country this season, as well as his eighth in his last seven games.

But West Ham responded well to that setback and grabbed an equaliser in the 25th minute.

Kevin Nolan laid the ball off to Carroll in a dangerous position in the penalty area and former West Ham midfielder Scott Parker, lunging in to block, made clear contact on Carroll, forcing referee Howard Webb to give the spot-kick.

England forward Carroll, on loan from Liverpool, stepped up to smash the penalty past Hugo Lloris for his third goal of the season.

Jan Vertonghen almost restored Tottenham's lead in the opening moments of the second half when his cross deflected off Guy Demel and forced Jaaskelainen into a scrambling save.

Jaaskelainen, called into action again from the resulting corner to push away Steven Caulker's towering header, was keeping Spurs at bay almost single-handed.

He turned Sigurdsson's long-range shot onto a post and when the rebound fell to Emmanuel Adebayor, the Hammers goalkeeper leapt to his feet to block the follow-up.

After those escapes, West Ham moved ahead in the 58th minute when Cole collected Joey O'Brien's lofted pass with a fine first touch and turned to bury his shot beyond Lloris.

Tottenham kept pressing and, after Matt Taylor missed a golden chance to extend West Ham's lead, the visitors levelled when Sigurdsson prodded home at the far post from Bale's free-kick.

That set the stage for a pulsating finish and after more heroics from Jaaskelainen, Bale took charge, producing a truely stunning strike from 30 yards to seal the points.

- AFP/ac



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Army renews hunt for bunker-bursting rifles 8 years after bribery scandal

NEW DELHI: The Army is launching a fresh hunt for anti-material rifles, meant for "bunker-bursting" as well as "penetrating" light-armoured vehicles, eight years after its earlier project with South African company Denel got derailed mid-way due to kickback allegations and political mudslinging.

The Army is now ready with the technical parameters, or GSQRs (general staff qualitative requirements), for the fresh global tender for the anti-material rifles. The force wants the rifle — weighing not over 15 kg to ensure two soldiers can carry it -- with an effective range of over 1,000-metre to take on enemy bunkers and other field fortifications, "soft-skinned" armoured vehicles and low-flying helicopters, say sources.

The new anti-material rifle project will be a major one, with the first lot being imported directly and the rest indigenously manufactured after transfer of technology (ToT). The Army, apart from its other arms, wants each of its 355 infantry battalions to have at least four such specialized rifles that can fire special calibre high-explosive incendiary/armour-piercing ammunition.

The long-delayed quest for these rifles is just one of the several military modernization projects that have gone for a toss due to corruption scams and consequent blacklisting of armament majors. "The guilty should be hung...the entire procurement system needs to be overhauled to ensure national security requirements are not hit time and again," said a senior officer.

For instance, Army's failure to induct even a single advanced 155mm artillery gun since the Bofors scandal of the mid-1980s. "Blacklisting has proven counter-productive. Most major artillery manufacturers, like Denel, Rheinmetall, Singapore Technologies and Soltam, are blacklisted by India...It's only now the Ordnance Factory Board (OFB) and private players like the Tatas are developing 155mm howitzers," said a MoD official.

The anti-material rifles' story is similar. The UPA-I government in April 2005 had put on hold all dealings with Denel after it came to light that 12.75% commission was allegedly paid to a firm, Varas Associates, to swing the five contracts signed between July 1999 and March 2005.

The contracts were for 700 anti-material rifles and 398,000 rounds of ammunition, followed by ToT to OFB along with "knocked down kits" for another 300 rifles. The Army had inducted just around 300 rifles when the CBI registered the case in June 2005.

At that time, the Congress was using the case — along with the emergency purchases for the 1999 Kargil conflict and the Tehelka tapes — to go after George Fernandes, who was the defence minister in the NDA regime when the initial rifle contracts were inked. The CBI, however, is yet to make any major headway in the case.

Now, Army wants to induct light-weight anti-material rifles that are "man-portable" with a two-jawan crew. "The Denel rifles, while they have performed well, are quite heavy at 28-29 kg apiece. There are also major problems in importing its specialized bullets and ammunition," said an officer.

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Mediterranean-style diets found to cut heart risks


Pour on the olive oil, preferably over fish and vegetables: One of the longest and most scientific tests of a Mediterranean diet suggests this style of eating can cut the chance of suffering heart-related problems, especially strokes, in older people at high risk of them.


The study lasted five years and involved about 7,500 people in Spain. Those who ate Mediterranean-style with lots of olive oil or nuts had a 30 percent lower risk of major cardiovascular problems compared to those who were told to follow a low-fat diet but who in reality, didn't cut fat very much. Mediterranean meant lots of fruit, fish, chicken, beans, tomato sauce, salads, and wine and little baked goods and pastries.


Mediterranean diets have long been touted as heart-healthy, but that's based on observational studies that can't prove the point. The new research is much stronger because people were assigned diets to follow for a long time and carefully monitored. Doctors even did lab tests to verify that the Mediterranean diet folks were consuming more olive oil or nuts as recommended.


Most of these people were taking medicines for high cholesterol and blood pressure, and researchers did not alter those proven treatments, said one study leader, Dr. Ramon Estruch of Hospital Clinic in Barcelona.


But as a first step to prevent heart problems, "we think diet is better than a drug" because it has few if any side effects, Estruch said. "Diet works."


Results were published online Monday by the New England Journal of Medicine and were discussed at a nutrition conference in Loma Linda, Calif.


People in the study were not given rigid menus or calorie goals because weight loss was not the aim. That could be why they found the "diets" easy to stick with — only about 7 percent dropped out within two years. There were twice as many dropouts in the low-fat group than among those eating Mediterranean-style.


Researchers also provided the nuts and olive oil, so it didn't cost participants anything to use these relatively pricey ingredients. The type of oil may have mattered — they used extra-virgin olive oil, which is minimally processed and richer than regular or light olive oil in the chemicals and nutrients that earlier studies have suggested are beneficial.


The study involved people ages 55 to 80, just over half of them women. All were free of heart disease at the start but were at high risk for it because of health problems — half had diabetes and most were overweight and had high cholesterol and blood pressure.


They were assigned to one of three groups: Two followed a Mediterranean diet supplemented with either extra-virgin olive oil (4 tablespoons a day) or with walnuts, hazelnuts and almonds (a fistful a day). The third group was urged to eat a low-fat diet heavy on bread, potatoes, pasta, rice, fruits, vegetables and fish and light on baked goods, nuts, oils and red meat.


Independent monitors stopped the study after nearly five years when they saw fewer problems in the two groups on Mediterranean diets.


Doctors tracked a composite of heart attacks, strokes or heart-related deaths. There were 96 of these in the Mediterranean-olive oil group, 83 in the Mediterranean-nut group and 109 in the low-fat group.


Looked at individually, stroke was the only problem where type of diet made a big difference. Diet had no effect on death rates overall.


The Mediterranean diet proved better even though its followers ate about 200 calories more per day than the low-fat group did. The study leaders now are analyzing how each of the diets affected weight gain or loss and body mass index.


The Spanish government's health research agency initiated and paid for the study, and foods were supplied by olive oil and nut producers in Spain and the California Walnut Commission. Many of the authors have extensive financial ties to food, wine and other industry groups but said the sponsors had no role in designing the study or analyzing and reporting its results.


Rachel Johnson, a University of Vermont professor who heads the American Heart Association's nutrition committee, said the study is very strong because of the lab tests to verify oil and nut consumption and because researchers tracked actual heart attacks, strokes and deaths — not just changes in risk factors such as high cholesterol.


"At the end of the day, what we care about is whether or not disease develops," she said. "It's an important study."


Rena Wing, a weight-loss expert at Brown University, noted that researchers provided the oil and nuts, and said "it's not clear if people could get the same results from self-designed Mediterranean diets" — or if Americans would stick to them more than Europeans who are used to such foods.


Dr. George Bray of the Pennington Biomedical Research Center in Baton Rouge, La., said he would give the study "a positive — even glowing — comment" and called it "the best and certainly one of the largest prospective dietary trials ever done."


"The data are sufficiently strong to convince me to move my dietary pattern closer to the Mediterranean Diet that they outline," he added.


Another independent expert also praised the study as evidence diet can lower heart risks.


"The risk reduction is close to that achieved with statins," cholesterol-lowering drugs, said Dr. Robert Eckel, a diet and heart disease expert at the University of Colorado.


"But this study was not carried out or intended to compare diet to statins or blood pressure medicines," he warned. "I don't think people should think now they can quit taking their medicines."


___


Online:


Journal: http://www.nejm.org


___


Marilynn Marchione can be followed at http://twitter.com/MMarchioneAP


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Best Moments From the Academy Awards






Host Seth MacFarlane took the stage at the 2013 Oscars with an opening monologue revealing he was ready to poke fun at the star-studded audience.


"The quest to make Tommy Lee Jones laugh begins now," he said.


But it wasn't too long before MacFarlane was interrupted. William Shatner, dressed as his iconic character Captain Kirk from "Star Trek," descended on the stage to warn MacFarlane that he was about to ruin the Oscars and be branded the worst host ever.


"The show is a disaster. I've come back in time … to stop you from ruining the Academy Awards," Shatner said.

Seth MacFarlane's Boobs Tribute


Shatner tried to steer MacFarlane away from singing an "incredibly offensive song that upsets a lot of women in the audience."


Cue MacFarlane's medley "We Saw Your Boobs," a laundry list set to music of acclaimed actresses in Hollywood who all bared their breasts in film.


MacFarlane was joined by the Gay Men's Chorus of Los Angeles to call out Meryl Streep, Anne Hathaway, Naomi Watts, Jodie Foster, Hilary Swank and countless others who we've seen nude in film.



Not every joke funnyman Seth MacFarlane made landed with the A-list crowd at the 85th annual Academy Awards.


The host elicited gasps from the crowd when he introduced "Django Unchained" as "the story of a man fighting to get back his woman, who's been subjected to unthinkable violence. Or, as Chris Brown and Rihanna call it, a date movie."


Another joke that somehow earned a too-soon nod? A throw to President Abraham Lincoln's assassination.


"I'd argue that the actor who really got inside Lincoln's head was John Wilkes Booth," MacFarlane said.


MacFarlane's jab at Mel Gibson didn't land too smoothly either. MacFarlane said the N-word laden "Django Unchained" screenplay was "loosely based on Mel Gibson's voicemails."

Oscars' Movie Musical Tribute


The theme of the 85 annual Academy Awards was celebrating music in film, and the tributes to movie musicals didn't disappoint.


Featured performers included Catherine Zeta-Jones belting "All That Jazz" from 2002's Best Picture winner "Chicago," Jennifer Hudson's show-stopping "And I'm Telling You I'm Not Going" from 2006's "Dreamgirls," and the cast of this year's Best Picture nominee "Les Miserables" reuniting on stage for "One Day More."

Introducing the Von Trapp Family


To introduce Christopher Plummer to the stage to present the award for Best Supporting Actress, MacFarlane couldn't help but make a joke out of the actor's infamous role as Captain Von Trapp in "The Sound of Music."


MacFarlane came out to announce the Von Trapp family singers, but no one came out. Instead, a man dressed in a Nazi uniform ran in to tell him that they were gone.

Kristen Stewart Hobbles on Stage to Present


When Daniel Radcliffe took the stage to present the award for Achievement in Production Design, he was joined by his hobbling co-presenter Kristen Stewart, who was seen crutching along the red carpet during the pre-show.


The "Twilight" star's makeup artist told People magazine that the actress "cut the ball of her foot, quite severely, on glass two days ago."


The Associated Press reported that backstage, Best Supporting Actress winner Anne Hathaway told Stewart to "break a leg."

Jennifer Lawrence's Unstable Victory


Jennifer Lawrence was so shocked to take home the Oscar for Best Actress that she lost her footing on her way up to the stage to accept her award.


"You guys are just standing up because I fell and that's really embarrassing," she said to the audience.


Lawrence regained her composure to give her acceptance speech, extending a special thank you to "the women this year," who she called "so magnificent and so inspiring."

Daniel Day-Lewis a Three-Peat Best Actor Winner


It was a highly anticipated win for Daniel Day-Lewis, who took home the award for Best Actor for his portrayal of Abe Lincoln in Steven Spielberg's "Lincoln."


Lewis cracked a joke in his acceptance speech, saying he was supposed to be cast as Margaret Thatcher and presenter Meryl Streep was the first choice for Lincoln.


"Meryl Streep was Steven's first choice to play Lincoln… I'd like to see that version," Lewis said.

Michelle Obama Announces Best Picture Winner


In one of the biggest surprises of the night, the Academy brought out First Lady Michelle Obama to help Jack Nicholson introduce the nominees for Best Picture.


Rocking her new bangs and a silver gown, the first lady, live from the White House, announced "Argo" as this year's Best Picture.


"It was a thrill to announce the #Oscars2013 best picture winner from the @WhiteHouse! Congratulations Argo!" FLOTUS tweeted afterwards.

Ben Affleck Triumphs at Oscars


Ben Affleck was flabbergasted by his win for Best Picture for "Argo." His frenzied, heartfelt acceptance speech resonated as he thanked his wife, Jennifer Garner, and ended on an inspirational high note.


"I want to thank my wife, who I don't normally associate with Iran. I want to thank you for working on our marriage. It is work, but it is the best kind of work," he said.


"I was here 15 years ago or something and you know I had no idea what I was doing. I stood out here in front of you all, really just a kid. I went out and I never thought I'd be back here and I am because of so many of you who are here tonight …. I want to thank them for what they taught me, which is that you have to work harder than you think you possibly can, you can't hold grudges. It's hard, but you can't hold grudges. And it doesn't matter how you get knocked down in life because that's going to happen. All that matters is that you got to get up."


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Syrian opposition says captures former nuclear site


AMMAN (Reuters) - Syrian rebels have captured the site of a suspected nuclear reactor near the Euphrates river which Israeli warplanes destroyed six years ago, opposition sources in eastern Syria said on Sunday.


Al-Kubar site, around 60 km (35 miles) west of the city of Deir al-Zor, became a focus of international attention when Israel raided it in 2007. The United States said the complex was a North Korean-designed nuclear reactor geared to making weapons-grade plutonium.


Omar Abu Laila a spokesman for the Eastern Joint Command of the Free Syrian Army said the only building rebels found at the site was a hangar containing at least one Scud missile.


"It appears that the site was turned into a Scud launch base. Whatever structures it had have been buried," he said, adding that three army helicopters airlifted the last loyalist troops before opposition fighters overran the area on Friday.


The Syrian military, which razed the site after the Israeli raid, said the complex was a regular military facility but refused to allow the International Atomic Energy Agency unrestrained access, after the agency said the complex could have been a nuclear site.


The U.N. investigation appears to have died down since the national revolt against Preident Bashar al-Assad broke out in 2011, with the armed opposition increasingly capturing military sites in rural areas and on the edges of cities.


U.N. inspectors examined the site in June 2008 but Syrian authorities has barred them access since.


Abu Laila said Scuds appear to have been fired from Kubar at rebel-held areas in the province of Homs to the west.


The complex, he said, had command and control links with loyalist troops in the city of Deir al-Zor, where Assad's forces have been on the retreat and are now based mainly in and around the airport in the south of the city.


Footage showed fighters inspecting the site and one large missile inside a hangar. One fighter pointed to what he said were explosives placed under the missile to destroy it before attacking forces got to it.


Abu Hamza, a commander in the Jafaar al-Tayyar brigade, said in a YouTube video taken at Kubar that various rebel groups, including the al Qaeda linked al-Nusra front, took part the operation and that U.N. inspectors were welcome to come and survey the site.


In the last few months, opposition fighters have captured large swathes of the province of Deir al-Zor, a Sunni Muslim desert oil producing region that borders Iraq, including most of a highway along Euphrates leading to Kubar.


The province is far from the Assad's main military supply bases on the coast and in Damascus. Long-time alliances between Assad, who belongs to the minority Alawite sect, an offshoot of Islam, and Sunni tribes in Deir al-Zor have also largely collapsed since the revolt.


But Assad's forces remain entrenched in the south of the city of Deir al-Zor and armed convoys guarded by helicopters still reach the city from the city of Palmyra to the southwest, according to opposition sources.


(Editing by Stephen Powell)



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Football: Inter - Milan share spoils as Balotelli returns to derby






MILAN: AC Milan striker Mario Balotelli missed a handful of chances in his first derby in over three years as the Rossoneri shared the spoils in a 1-1 derby draw with hosts Inter Milan here Sunday.

Milan took a 21st minute lead through striker Stephan El Shaarawy and dominated throughout before ultimately lamenting their earlier misses when Inter midfielder Ezequiel Schelotto levelled in the 71st minute.

Inter were given a pre-match boost with the inclusion of central defender Andrea Ranocchia, who had been an injury doubt all week.

Yet despite Milan's 1-0 defeat to the Nerazzurri at the San Siro earlier in the campaign, the visitors started the second 'Derby della Madonnina' as firm favourites having stunned Barcelona 2-0 in their Champions League first leg here last week and climbed up to third place in the table.

Milan enjoyed the share of the early chances with Sulley Muntari and Mattia De Sciglio testing Samir Handanovic, while Inter striker Antonio Cassano saw a lame shot easily collected by Christian Abbiati.

However, the visitors spurned the first of several clear chances, Balotelli slipping in front of goal after Kevin Prince Boateng had left Mattia De Sciglio's cross from the left wing at his feet.

At the other end forward Rodrigo Palacio should have done better with an angled strike that went well side of Abbiati's far post.

Milan began to dictate play and were finding options down the left where De Sciglio's long runs were giving the hosts trouble.

When former Milan striker Cassano lost possession in midfield, Boateng collected and coolly sent El Shaarawy through to beat Handanvoic with an angled shot with the outside of his boot.

Milan threatened again when Balotelli rose to meet a corner from the right which had Handanovic scrambling for the ball on the goalline.

Balotelli's third clear chance followed moments later when he toe-poked a probing ball into the box only for it to be cleared.

Handanovic easily collected Balotelli's header from Ignazio Abbate's cross from the right but on 40 minutes the 'keeper was at full stretch to parry when Balotelli thumped a freekick from 30 metres out.

Milan threatened from the outset of the second half, Boateng flashing a header wide from Montolivo's freekick on the right after El Shaarawy had been hauled down.

Freddy Guarin gave Inter's fans hope when he first-timed Palacio's whipped cross in from the right only for Abbiati to pull off a superb save at full stretch.

On 57 minutes Balotelli flashed a header wide from a freekick but was left far more frustrated when Handanovic bravely blocked as the striker got in close to try and prod the ball home from a cross on the right.

Milan were still dominating, but the visitors were stunned in the 71st minute when Schelotto got on the end of Yuto Nagatomo's cross to stun Abbiati only two minutes after replacing Cambiasso.

Inter had the momentum and moments later Palacio's header to the right of Abbiati's goal had the keeper scrambling, although at the other end Muntari sent a looping shot just to the right of an outstretched Handanovic.

Milan regrouped to dominate the final quarter hour, with El Shaarawy's ambitious bicycle kick blocked and then M'Baye Niang, who replaced Boateng with 10 minutes to go, seeing his low strike meet traffic in the area.

However the Rossoneri were lucky not to suffer a late Inter goal against the run of play when Palacio saw a header go close.

- AFP/jc



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